Book
Medical Virology
David O. White
Frank J. Fenner
Academic Press, Inc.
ISBN 0-12-746642-8
1994
Legend
Computer graphics representation of the virion of human rhinovirus 14 along the icosahedral 3-fold axis of symmetry, highlighting the topographic details of the surface. Lighter colored structures are situated further away from the virion center, showing that the 5-fold axis region is the most prominent feature. The “canyon” is clearly seen as a dark blue depression around the 5-fold axis and is the binding site for the cellular receptor ICAM-1. A depression is visible at the icosahedral 2-fold axis of symmetry (equidistant between two 5-fold vertices), but has no known role. Antibody binding sites determined by escape mutations are shown in magenta and clearly appear in more exposed (white or light blue) areas on “domes” and “ridges”, suggesting that the dark and blue areas are not within the reach of antibodies.
Image created by JY Sgro
Image
Created on Silicon Graphics system from series of software:
MS- Connolly Surface (references within)B-pline- Nathalie Colloc’h- JYS scripts.
Click on images to see larger versions.
